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INTRODUCTION
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The Mouse. Additional sources of information. General The laboratory mouse, Mus musculus, belongs to the order Rodentia and family Muridae. The mouse is probably the most genetically and biologically characterized mammal in the world. Mice were first used for the study of respiration in the 17th century. Later in the 19th and 20th century they were bred for their coat color, and subsequently characterized genetically. Most of the common laboratory strains were developed in the early s. The mouse has short hair, a long naked tail, rounded erect ears, protruding eyes, a pointed snout and five toes on each foot. Mice come in a variety of colors. Insert picture of a mouse, get those cool ones.
Description of Stages of Estrous Cycle and Hormonal Considerations
The short reproductive cycle length observed in rodents, called the estrous cycle, makes them an ideal animal model for investigation of changes that occur during the reproductive cycle. Most of the data in the literature about the estrous cycle is obtained from rat because they are easily manipulated and exhibit a clear and well defined estrous cycle. However, the increased number of experiments using knockout mice requires identification of their estrous cycle as well, since in fertility issues may arise. In mice, like rats, the identification of the stage of estrous cycle is based on the proportion of cells types observed in the vaginal secretion. The aim of this unit is to provide guidelines for quickly and accurately determining estrous cycle phases in mice. In humans, the reproductive cycle, called the menstrual cycle, lasts approximately 28 days, in rodents this cycle, called the estrous cycle, lasts approximately days.
Metrics details. With each trajectory taken during the ontogeny of an individual, the number of optional behavioural phenotypes that can be expressed across its life span is reduced. In mammalian species, the phenotype is shaped as the foetus grows, depending on the environment in the uterus, which in turn depends on the outer environment the mother experiences during pregnancy. After birth, a complex interaction between innate constitution and environmental conditions shapes individual lifetime trajectories, bringing about a wide range of diversity among individual subjects.
